Saturday, March 30, 2013

Drugs used in Tuberculosis


Drugs used in Tuberculosis:-

Bacteria: Mycobacterium Tuberculosis

Drugs, anti TB
Mode of action
  1. Primary agent
  2.  Isoniazid

  3.  Ethambutol

  4.  Rifampin

  5.  Pyrazinamide

Ihibits synthesis of mycolic acid

Ihibit lipid synthesis

Inhibits DNA dependent RNA polymerase

unknown
  1. Secondary agents
  2. Streptomycin



  3. p-amino Salicylic acid
    4. (PASA)

  4. Cycloserine

  5. Ethionamide

Binds to 30s ribosomes,
Inhibits polysome formation &
misreads m-RNA in protein synthesis

Competitive inhibitor of PABA in folate synthesis,
Inhibits protein capreomycin synthesis

Inhibits bacterial cell wall synthesis

Probably inhibits mycolic acid synthesis
  1. Alternative agents
  2. Rifabutin

  3. Quinolones

  4. Macrolides

Inhibits DNA dependent RNA polymerase

Inhibits DNA gyrase

Binds to 50s ribosome and
prevents translocation in protein synthesis
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